Natural allelic variation of the IL-21 receptor modulates ischemic stroke infarct volume. A genome-wide association study identifies six novel risk loci for primary biliary cholangitis. Upregulation of Interleukin 21 and Interleukin 21 Receptor in Patients with Dermatomyositis and Polymyositis. Chitosan nanoparticle-based delivery of fused NKG2D-IL-21 gene suppresses colon cancer growth in mice. IL-21/IL-21R inhibit tumor growth and invasion in non-small cell lung cancer cells via suppressing Wnt/ß-catenin signaling and PD-L1 expression. Effects of treatment with hydroxychloroquine on the modulation of Th17/Treg ratio and pregnancy outcomes in women with recurrent implantation failure: clinical trial. IL-21 promotes osteoblastic differentiation of human valvular interstitial cells through the JAK3/STAT3 pathway. Dot Blot protocol technique for detecting, analyzing, and identifying proteins, similar to the western blot technique but differing in that protein samples are not separated electrophoretically but are spotted through circular templates directly onto the membrane or paper substrate. Circulating follicular T helper cells and humoral reactivity in rheumatic heart disease. A novel vaccinia virus enhances anti-tumor efficacy and promotes a long-term anti-tumor response in a murine model of colorectal cancer. Publishing research using ab5978? Please let us know so that we can cite the reference in this datasheet.Īb5978 has been referenced in 9 publications. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Please check that this product meets your needs before purchasing. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. The Life Science industry has been in the grips of a reproducibility crisis for a number of years. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations. IL-21 is expressed in activated T cells, and HL-60 and THP-1 cell lines. IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21R forms a complex with the common cytokine receptor g chain, gc, and mediates IL-21 signaling. The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family. A novel cytokine was recently identified in human and mouse and designated IL-21, which has significant homology to IL-2, IL-4, and IL-15.
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